The effects of APOE genotype on cognitive function

 
   Lead Investigator:    Mitsuru Shinohara
   Institution      :    Mayo Clinic
   E-Mail           :    shinohara@ncgg.go.jp
   Proposal ID      :    486


   Publications:


1  Shinohara M, Kanekiyo T, Yang L, Linthicum D, Shinohara M, Fu Y, Price L, Penuliar MS, Wang M, Han X, Fryer J, Bu G
   APOE2 eases cognitive decline during aging: clinical and preclinical evaluations
   Journal Article  Ann Neurol,5:758-774,2016,PMC5010530

   PUBLISHED





   Proposal Description:
   Numerous studies demonstrated that APOE4 deteriorate cognitive function especially related with AD-vulnerable tasks, such as episodic memory and working memory even without development of Alzheimer???s disease. On the other hand, a few study investigated the effect of APOE2, protective risk factor for AD, on cognitive function. We aims to compare the effects of APOE2, APOE3, and APOE4 genotype on cognitive function with/without development of Alzheimer???s disease by cross sectional and longitudinal approaches. Specific aim 1:  We will longitudinally study how the presence of AD-risk factor APOE4 and AD-protective factor APOE2 affect the cognitive function in people with cognitively normal, MCI or Alzheimer???s disease patients. Specific aim 2:  We will cross-sectionally study how the presence of AD-risk factor APOE4 and AD-protective factor APOE2 affect cognitive function in people with cognitively normal, MCI or Alzheimer???s disease patients.